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See our breakdown of MOTS-c for weight loss, including what the research shows and realistic expectations for more on the fat loss angle specifically

Area under the curve (AUC), clearance (CL), volume of distribution at steady-state (V ss ), and elimination half-life (t 1/2 ) were calculated by non-compartmental analysis (NCA) using the custom-made software DDS-Tox developed by Nuvisan GmbH, which provides results comparable to Phoenix WinNonlin (Certara, L.P., Princeton, New Jersey, USA)

A good example is the finding that low circulating levels of IGF-1 are independently associated with hyperglycaemia and insulin resistance in adults [160, 230232]